مشخصات کلی Circulating levels of irisin in hypopituitary and normal subjects

نویسنده کتاب (Author):

Pena-Bello, Lara; Pértega-Díaz, Sonia; Sangiao-Alvarellos, Susana; Outeiriño-Blanco, Elena; Eiras-Leal, Raquel; Varela-Rodríguez, BM; Juiz-Valiña, Paula; Pérez Fontán, Miguel; Cordido, María; Cordido Carballido, Fernando

انتشارات (Publisher):

PLoS ONE 2016-07-29

ویرایش و نوع فایل (Edition/Format):

 Downloadable article : English

منبع (Database):

WorldCat

عنوان ژورنال (Publication):

pena-bello-l-pertega-diaz-s-sangiao-alvarellos-s-et-al-circulating-levels-of-irisin-in-hypopituitary-and-normal-subjects-plos-one-internet-2016117e0160364

توضیحات خلاصه (Summary):

[Abstract] Context. The recently identified myokine irisin conveys some of the benefits of exercise. Hypopituitarism with adult growth hormone deficiency (HP) is a situation characterized by decreased GH secretion and an altered body composition. Objective. Our aim was to study the skeletal muscle hormone irisin in HP, and compare the results with a similar group of normal subjects. Participants and Methods. Seventeen HP patients and fifty-one normal subjects of similar age and sex were studied. The diagnosis of GH deficiency was confirmed by the presence of pituitary disease and a peak GH secretion below 3 μg/L after an insulin tolerance test. The patients were adequately treated for all pituitary hormone deficits, except for GH. Fasting serum irisin was measured with an enzyme immunoassay, and HOMA-IR, QUICKI and HOMA-β were calculated. Results. Fasting irisin levels (ng/ml) were similar in normal [208.42 (168.44–249.23)] and HP patients [195.13 (178.44–241.44)]. In the control group there were moderate significant positive correlations between irisin and BMI, waist circumference, leptin, fasting insulin, HOMA-IR, HOMA-β, triglycerides, and cholesterol. In the control group there were moderate significant negative correlations between irisin and IGF-I and QUICKI. In the hypopituitary group there were moderate significant positive correlations between irisin and body fat and HOMA-β. Conclusions. We found similar irisin levels in GH deficiency hypopituitary patients when compared with normal subjects. The correlation between irisin and adiposity related factors suggests that that in the case of this clinical model, irisin is regulated by adiposity and not by GH.  Read more…

ژانر / فرم:info:eu-repo/semantics/article

موضوع:Internet resource

نوع منبع:Internet Resource, Article

تمام نویسندگان / همکاران: Pena-Bello, Lara; Pértega-Díaz, Sonia; Sangiao-Alvarellos, Susana; Outeiriño-Blanco, Elena; Eiras-Leal, Raquel; Varela-Rodríguez, BM; Juiz-Valiña, Paula; Pérez Fontán, Miguel; Cordido, María; Cordido Carballido, Fernando

شناسه OCLC:979265472

Language Note:English

فهرست محتوا:1932-6203 http://hdl.handle.net/2183/18225

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